Effectiveness of premedication for hypersensitivity reactions to radiocontrast media in one tertiary hospital

Results A total of 401 patients with a history of hypersensitivity reaction to RCM and were premedicated at re-exposure to RCM. Male was 177 (44.1%) and mean age was 55.83¡3⁄411.92 years. Most common hypersensitivity symptom was urticaria (259, 64.6%), followed by itching (36.7%), rash (21.4%) and angioedema (13.2%). Hypotension was reported in 9 (2.2%) and syncope 5 (1.2%). Systemic steroid was prescribed in 143 patients (35.4%). After premedication, 139 patients (77.7%) had no hypersensitivity reactions to re-exposed RCM. Incidence of symptom after premedication such as uriticaria (12.4%), itching (5.6%), rash (5.1%), angioedema (2.2%) were significantly decreased compared with previous incidence (P<0.001). However, incidence of hypotension (1.1%) and syncope (0.6%) were no significant different with previous incidence (P>0.05)